Investigation of In Vivo skin stiffness anisotropy in breast cancer related lymphoedema.
Identifieur interne : 000F35 ( Main/Exploration ); précédent : 000F34; suivant : 000F36Investigation of In Vivo skin stiffness anisotropy in breast cancer related lymphoedema.
Auteurs : L V Coutts [Royaume-Uni] ; N R Miller [Royaume-Uni] ; Peter Mortimer (dermatologue) [Royaume-Uni] ; J C Bamber [Royaume-Uni]Source :
- Journal of biomechanics [ 1873-2380 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- physiopathologie : Bras, Lymphoedème, Peau, Région mammaire, Tumeurs du sein.
- Adulte, Adulte d'âge moyen, Anisotropie, Femelle, Humains, Sujet âgé, Volontaires sains.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Arm, Breast, Breast Neoplasms, Lymphedema, Skin.
- Adult, Aged, Anisotropy, Female, Healthy Volunteers, Humans, Middle Aged.
Abstract
There is a limited range of suitable measurement techniques for detecting and assessing breast cancer related lymphoedema (BCRL). This study investigated the suitability of using skin stiffness measurements, with a particular focus on the variation in stiffness with measurement direction (known as anisotropy). In addition to comparing affected tissue with the unaffected tissue on the corresponding site on the opposite limb, volunteers without BCRL were tested to establish the normal variability in stiffness anisotropy between these two corresponding regions of skin on each opposite limb. Multi-directional stiffness was measured with an Extensometer, within the higher stiffness region that skin typically displays at high applied strains, using a previously established protocol developed by the authors. Healthy volunteers showed no significant difference in anisotropy between regions of skin on opposite limbs (mean decrease of 4.7 +/-2.5% between non-dominant and dominant arms), whereas BCRL sufferers showed a significant difference between limbs (mean decrease of 51.0+/-16.3% between unaffected and affected arms). A large difference in anisotropy was apparent even for those with recent onset of the condition, indicating that the technique may have potential to be useful for early detection. This difference also appeared to increase with duration since onset. Therefore, measurement of stiffness anisotropy has potential value for the clinical assessment and diagnosis of skin conditions such as BCRL. The promising results justify a larger study with a larger number of participants.
DOI: 10.1016/j.jbiomech.2015.11.043
PubMed: 26684433
Affiliations:
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Electronic address: louisevcoutts@gmail.com.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Joint Department of Physics, Surrey, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Miller, N R" sort="Miller, N R" uniqKey="Miller N" first="N R" last="Miller">N R Miller</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Joint Department of Physics, Surrey, England, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Joint Department of Physics, Surrey, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Cell Sciences (Dermatology Unit), St George׳s Hospital, University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Cell Sciences (Dermatology Unit), St George׳s Hospital, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Bamber, J C" sort="Bamber, J C" uniqKey="Bamber J" first="J C" last="Bamber">J C Bamber</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Joint Department of Physics, Surrey, England, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Joint Department of Physics, Surrey, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of biomechanics</title><idno type="eISSN">1873-2380</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anisotropy</term><term>Arm (physiopathology)</term><term>Breast (physiopathology)</term><term>Breast Neoplasms (physiopathology)</term><term>Female</term><term>Healthy Volunteers</term><term>Humans</term><term>Lymphedema (physiopathology)</term><term>Middle Aged</term><term>Skin (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anisotropie</term><term>Bras (physiopathologie)</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (physiopathologie)</term><term>Peau (physiopathologie)</term><term>Région mammaire (physiopathologie)</term><term>Sujet âgé</term><term>Tumeurs du sein (physiopathologie)</term><term>Volontaires sains</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Bras</term><term>Lymphoedème</term><term>Peau</term><term>Région mammaire</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term><term>Breast</term><term>Breast Neoplasms</term><term>Lymphedema</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anisotropy</term><term>Female</term><term>Healthy Volunteers</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anisotropie</term><term>Femelle</term><term>Humains</term><term>Sujet âgé</term><term>Volontaires sains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a limited range of suitable measurement techniques for detecting and assessing breast cancer related lymphoedema (BCRL). This study investigated the suitability of using skin stiffness measurements, with a particular focus on the variation in stiffness with measurement direction (known as anisotropy). In addition to comparing affected tissue with the unaffected tissue on the corresponding site on the opposite limb, volunteers without BCRL were tested to establish the normal variability in stiffness anisotropy between these two corresponding regions of skin on each opposite limb. Multi-directional stiffness was measured with an Extensometer, within the higher stiffness region that skin typically displays at high applied strains, using a previously established protocol developed by the authors. Healthy volunteers showed no significant difference in anisotropy between regions of skin on opposite limbs (mean decrease of 4.7 +/-2.5% between non-dominant and dominant arms), whereas BCRL sufferers showed a significant difference between limbs (mean decrease of 51.0+/-16.3% between unaffected and affected arms). A large difference in anisotropy was apparent even for those with recent onset of the condition, indicating that the technique may have potential to be useful for early detection. This difference also appeared to increase with duration since onset. Therefore, measurement of stiffness anisotropy has potential value for the clinical assessment and diagnosis of skin conditions such as BCRL. The promising results justify a larger study with a larger number of participants.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Coutts, L V" sort="Coutts, L V" uniqKey="Coutts L" first="L V" last="Coutts">L V Coutts</name></noRegion><name sortKey="Bamber, J C" sort="Bamber, J C" uniqKey="Bamber J" first="J C" last="Bamber">J C Bamber</name><name sortKey="Miller, N R" sort="Miller, N R" uniqKey="Miller N" first="N R" last="Miller">N R Miller</name><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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